PDE4DIP

Overview

PDE4DIP (phosphodiesterase 4D interacting protein) encodes a centrosome-associated scaffold protein (also known as myomegalin). It is involved in centrosome function and cAMP signaling. In cancer, PDE4DIP has been identified as part of a cluster of centrosome-associated genes with recurrent damaging mutations in small cell lung cancer.

Alterations observed in the corpus

• Clustered mutations in centrosome-associated genes including PDE4DIP, ASPM, and ALMS1 in small cell lung cancer (SCLC). PMID:26168399

Cancer types (linked)

• Small cell lung cancer (SCLC): Clustered mutations as part of a centrosome-associated gene cluster. PMID:26168399

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26168399

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