PDGFA

Overview

PDGFA (Platelet Derived Growth Factor Subunit A) encodes a ligand for the PDGF receptor tyrosine kinases. It was identified as a recurrently amplified locus in pancreatic ductal adenocarcinoma by GISTIC analysis.

Alterations observed in the corpus

  • In pancreatic ductal adenocarcinoma (PAAD), PDGFA (7p22.3) was identified as a recurrently amplified locus by GISTIC analysis in the 109-case microdissected whole-exome sequencing cohort. PMID:25855536

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • No specific co-occurrence or mutual exclusivity patterns reported in the corpus.

Therapeutic relevance

  • PDGF-receptor pathway inhibitors (e.g., PDGFR family inhibitors) are among FDA-targetable alterations noted in HCC (PDGFR family ~3% of cases) in related corpus papers.

Open questions

  • Functional significance of PDGFA amplification in PAAD as a driver vs. bystander event remains to be validated.

Sources

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