PDSS2

Overview

PDSS2 (Prenyl Diphosphate Synthase Subunit 2) encodes a component of the coenzyme Q biosynthesis pathway. In uveal melanoma, PDSS2 has been identified as a fusion partner in a structural variant detected by whole-genome sequencing.

Alterations observed in the corpus

• FAM135B-PDSS2 in-frame interchromosomal fusion detected in uveal melanoma sample 550 (chromosomes 6 and 8) by WGS PMID:26683228

Cancer types (linked)

• Uveal melanoma: interchromosomal fusion with FAM135B; single case, functional significance unknown PMID:26683228

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional consequence of the FAM135B-PDSS2 fusion in uveal melanoma is uncharacterized PMID:26683228

Sources

• PMID:26683228

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