PDXDC1

Overview

PDXDC1 (Pyridoxal Dependent Decarboxylase Domain Containing 1) is a gene significantly mutated in chromophobe renal cell carcinoma (chRCC) identified in a comprehensive multisubtype non-clear-cell RCC genomic study. Its functional role in cancer is uncharacterized.

Alterations observed in the corpus

  • Significantly mutated in chRCC in a multisubtype nccRCC WES study; oncogenic vs passenger status unestablished PMID:25401301

Cancer types (linked)

  • chRCC: significant mutation frequency in discovery cohort; co-nominated with PTEN, FAAH2, PDHB, and ZNF765 as chRCC-enriched SMGs PMID:25401301

Co-occurrence and mutual exclusivity

  • Co-nominated with PTEN, FAAH2, PDHB, and ZNF765 as significantly mutated genes in chRCC PMID:25401301

Therapeutic relevance

  • No targeted therapies established; functional characterization lacking PMID:25401301

Open questions

  • PDXDC1 lacks functional characterization in cancer — oncogenic vs passenger status is unestablished PMID:25401301

Sources

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