PGR

Overview

PGR encodes the progesterone receptor, a nuclear hormone receptor that mediates progesterone signaling and plays a central role in uterine biology. In endometrial cancer, PGR expression is a marker of hormonal responsiveness and is characteristically elevated in the lower-grade, copy-number-low endometrioid subtype. Loss of PGR expression is associated with more aggressive, hormone-insensitive disease.

Alterations observed in the corpus

  • Protein expression increased in the copy-number-low endometrial cancer cluster by RPPA, consistent with hormonal-therapy responsiveness of this endometrioid subgroup PMID:23636398
  • PR expression correlates with ER expression across CRISPR rat mammary tumor models; PGR transcript appears in the 58-gene set responsive to fulvestrant in rat tumors and in human GSE5462/GSE71791 datasets PMID:26437033
  • PGR (progesterone receptor) discussed as a candidate alternative activator of AR-pathway output in mCRPC tumors with AR activity but absent AR protein expression, alongside NR3C1 (GR) and ESR1 (ER-alpha). PMID:26928463

Cancer types (linked)

  • UCEC (Uterine Corpus Endometrial Carcinoma): PGR protein upregulation is a feature of the copy-number-low MSS endometrioid molecular subgroup, which is associated with better prognosis and potential sensitivity to progestin-based hormonal therapy PMID:23636398

Co-occurrence and mutual exclusivity

  • Elevated PGR expression co-occurs with the copy-number-low endometrioid molecular subtype, which is defined by CTNNB1 mutations and low overall genomic instability PMID:23636398

Therapeutic relevance

  • High PGR expression in copy-number-low endometrioid tumors supports the use of progestin-based hormonal therapies in this subgroup, as proposed by TCGA endometrial cancer molecular classification PMID:23636398

Open questions

  • Whether PGR protein levels (RPPA) correlate with clinical response to progestin therapy in prospective endometrial cancer cohorts remains to be demonstrated.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:26437033

This page was processed by crosslinker on 2026-05-14. - PMID:26928463

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