PIEZO2

Overview

PIEZO2 encodes a mechanosensitive ion channel component involved in proprioception and touch sensation. It has been identified as a recurrently mutated gene in endometrial polyps, with possible biallelic events suggesting a tumor-suppressor role in this context.

Alterations observed in the corpus

  • Possible biallelic events (missense + loss-of-function) identified as recurrently mutated in endometrial polyps (WGS, 23 polyps); listed alongside ARHGAP35 as a gene with potential biallelic inactivation PMID:28445112.

Cancer types (linked)

  • UCEC / ULM: PIEZO2 recurrent mutations in endometrial polyps, which can serve as precursor lesions to endometrial cancer PMID:28445112.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No specific therapeutic relevance reported for PIEZO2 in this corpus; functional biallelic loss suggests a possible tumor-suppressor role warranting further investigation PMID:28445112.

Open questions

  • The functional significance of biallelic PIEZO2 inactivation in endometrial polyp biology and malignant progression risk has not been established PMID:28445112.

Sources

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