PNKD

Overview

PNKD (Paroxysmal Nonkinesigenic Dyskinesia) is a gene newly nominated as significantly mutated in papillary renal cell carcinoma (pRCC) in a comprehensive multisubtype non-clear-cell RCC genomic study. Its functional role in cancer is uncharacterized.

Alterations observed in the corpus

• Newly nominated significantly mutated gene in pRCC; lacks functional characterization in cancer; oncogenic vs passenger status unestablished PMID:25401301

Cancer types (linked)

• pRCC: significant mutation frequency in discovery cohort; co-nominated with NF2, SLC5A3, CPQ, LRP2, CHD3, NHERF1, SETD2, and CRTC1 PMID:25401301

Co-occurrence and mutual exclusivity

• Co-nominated with NF2, SLC5A3, CPQ, LRP2, CHD3, NHERF1, SETD2, and CRTC1 as significantly mutated genes in pRCC PMID:25401301

Therapeutic relevance

• No targeted therapies established; functional characterization lacking PMID:25401301

Open questions

• PNKD lacks functional characterization in pRCC — oncogenic vs passenger status is unestablished PMID:25401301

Sources

• PMID:25401301

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