POC5

Overview

POC5 encodes a centriole assembly protein. In cancer genomics it is notable as a fusion partner in POC5-PRKD1, a novel fusion identified in polymorphous low-grade adenocarcinoma (PLGA) of the tongue.

Alterations observed in the corpus

• POC5-PRKD1 novel fusion identified in polymorphous low-grade adenocarcinoma of the tongue in the MET500 pan-cancer metastatic cohort (n=500) PMID:28783718

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• The functional consequences and therapeutic implications of the POC5-PRKD1 fusion are not yet characterized.

Sources

• PMID:28783718

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