PPARGC1A

Overview

PPARGC1A (PPARG Coactivator 1 Alpha; also PGC-1α) encodes a master transcriptional coactivator of mitochondrial biogenesis and oxidative metabolism. In cancer genomics, elevated PPARGC1A expression marks tumors with a non-Warburg, oxidative metabolic phenotype, particularly chromophobe renal cell carcinoma.

Alterations observed in the corpus

• Significantly elevated mRNA in chromophobe RCC vs normal kidney (p<1E-5), consistent with increased mitochondrial biogenesis and the non-Warburg metabolic phenotype that distinguishes ChRCC from ccRCC PMID:25155756

Cancer types (linked)

• ChRCC: overexpressed; marker of increased mitochondrial biogenesis; distinguishes ChRCC from ccRCC at the metabolic level PMID:25155756

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25155756

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