PPP2R5A

Overview

PPP2R5A encodes the B56-alpha regulatory subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase involved in cell cycle regulation, apoptosis, and signal transduction. In cancer contexts, PPP2R5A has been discussed as a target of SF3B1-driven mis-splicing, providing cross-disease context for the mechanisms of splicing-factor mutations in cancer.

Alterations observed in the corpus

• Discussed as a comparison target of SF3B1-driven mis-splicing in other cancers (breast cancer context); not directly altered in the SF3B1/del(13q) CLL cohort but provides cross-disease splicing context. PMID:26200345

Cancer types (linked)

• CLL/SLL (CLLSLL): Cross-disease comparison target for SF3B1-driven mis-splicing. PMID:26200345

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26200345

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