PRIM2
Overview
PRIM2 encodes the large subunit of DNA primase, the enzyme that synthesizes the short RNA primers required for DNA replication. In cancer genomics, PRIM2 has been identified as a recurrent structural rearrangement target in glioblastoma multiforme (GBM), suggesting a potential role in genomic instability.
Alterations observed in the corpus
- Recurrent intragenic somatic rearrangement in GBM (n=3 in WGS cohort of 42); identified among the most frequent recurrent structural events alongside EGFR (n=12) and CPM (n=3) PMID:24120142
Cancer types (linked)
- GBM — recurrent intragenic structural rearrangement detected in the TCGA GBM comprehensive genomic characterization WGS subset PMID:24120142
Co-occurrence and mutual exclusivity
- Co-identified as a structural rearrangement target in the same GBM cohort as EGFR, CPM, FAM65B, PPM1H, RBM25, and HOMER2 PMID:24120142
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus.
Open questions
- Functional significance of recurrent PRIM2 intragenic rearrangements in GBM is not established; it is unclear whether these are driver events or passenger structural alterations.
Sources
This page was processed by crosslinker on 2026-05-09.