PRKCB

Overview

PRKCB (Protein Kinase C Beta) encodes a serine/threonine kinase involved in signal transduction downstream of antigen receptors and growth factors. In cancer genomics, it is a direct transcriptional target of the EWS::FLI1 fusion oncogene in Ewing sarcoma and has been validated as a Ewing sarcoma dependency.

Alterations observed in the corpus

• Strongly induced novel direct EWS::FLI1 target in heMSCs (EWS::FLI1 binds intron 7); knockdown via EWS::FLI1 siRNA abolishes induction; reaffirmed as a Ewing sarcoma dependency consistent with Surdez et al. PMID:25186949

Cancer types (linked)

• Ewing sarcoma: direct EWS::FLI1 transcriptional target; validated dependency PMID:25186949

Co-occurrence and mutual exclusivity

Therapeutic relevance

• PRKCB is a Ewing sarcoma-restricted dependency; proposed as a potential therapeutic target PMID:25186949

Open questions

Sources

• PMID:25186949

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