PRKCZ
Overview
PRKCZ (Protein Kinase C Zeta) encodes an atypical serine/threonine kinase that is part of the PKC family. It plays roles in cell polarity, proliferation, and survival signaling. In cancer genomics, it has been identified as a candidate driver in breast cancer through computational driver network analyses.
Alterations observed in the corpus
- Mutation identified in 1 case in a WGS study of 65 triple-negative breast cancers (TNBC); ranked 32nd by driverNet driver scoring PMID:22495314
Cancer types (linked)
- Breast cancer (TNBC): candidate driver gene identified by network-based driver analysis PMID:22495314
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Single-case observation in a small cohort (n=65); larger studies needed to confirm recurrence and driver status.
Sources
This page was processed by entity-page-writer on 2026-05-06.