PROM1
Overview
PROM1 (Prominin 1), also known as CD133, is a pentaspan transmembrane glycoprotein widely used as a cancer stem cell (CSC) surface marker across multiple tumor types. In the neuroblastoma single-nuclei RNA-seq dataset from Bedoya-Reina et al. 2021, PROM1 is mentioned in the context of neuroblastoma cellular identity and progenitor populations.
Alterations observed in the corpus
- PROM1 is listed among the genes characterizing neuroblastoma tumor clusters in a single-nuclei RNA-seq study of 11 neuroblastoma tumors spanning different INRG risk groups and INSS stages (Smart-Seq2, 3,212 high-quality nuclei). PMID:34493726
Cancer types (linked)
- NBL — detected in neuroblastoma single-nuclei transcriptomic dataset; specific cluster association not further detailed in the corpus. PMID:34493726
Co-occurrence and mutual exclusivity
- Not specifically reported in the corpus.
Therapeutic relevance
- No direct targeted therapy is reported in the corpus for PROM1 in neuroblastoma.
Open questions
- The precise cluster expression pattern and prognostic significance of PROM1/CD133 in neuroblastoma were not explicitly detailed in the single-cell analysis. PMID:34493726
Sources
This page was processed by entity-page-writer on 2026-04-15.