PSCA
Overview
PSCA encodes prostate stem cell antigen, a GPI-anchored cell surface glycoprotein expressed in prostate, bladder, pancreas, and gastric epithelium. GWAS studies have identified PSCA variants as low-penetrance gastric cancer susceptibility loci, particularly in Asian populations. PSCA rs2294008 is among the best-replicated gastric cancer risk variants and may influence PSCA expression in gastric mucosa.
Alterations observed in the corpus
- Low-penetrance GWAS susceptibility locus for gastric cancer; individually small risk increment but clustering in a single family may partly explain familial aggregation of gastric cancer PMID:24816255
Cancer types (linked)
- Gastric cancer (STAD): PSCA identified as a low-penetrance gastric cancer risk locus from GWAS; co-evaluated with MUC1, PLCE1, and PRKAA1 in familial non-hereditary gastric cancer (FNHGC) risk assessment PMID:24816255
Co-occurrence and mutual exclusivity
- Co-evaluated with other low-penetrance gastric cancer susceptibility loci including MUC1, PLCE1, and PRKAA1 PMID:24816255
Therapeutic relevance
- No direct therapeutic targeting in the current corpus; PSCA variant status may contribute to polygenic gastric cancer risk models, though PRS for GC are not yet clinically actionable PMID:24816255
Open questions
- Whether PSCA susceptibility variants operate through differential expression in gastric epithelium or through altered PSCA protein function in H. pylori-associated carcinogenesis remains unresolved PMID:24816255
Sources
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