PTGFRN

Overview

PTGFRN (prostaglandin F2 receptor inhibitor) encodes a membrane protein involved in prostaglandin signaling and tetraspanin-enriched membrane domains. In cancer, PTGFRN has been identified as carrying clustered/damaging mutations in small cell lung cancer, with conservation of this alteration across human and murine SCLC models.

Alterations observed in the corpus

• Clustered/damaging mutations in small cell lung cancer (SCLC); also mutated in murine SCLC models, suggesting biological relevance across species. PMID:26168399

Cancer types (linked)

• Small cell lung cancer (SCLC): Clustered/damaging mutations; conservation in murine SCLC. PMID:26168399

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26168399

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