PTK7
Overview
PTK7 (Protein Tyrosine Kinase 7) encodes a catalytically inactive receptor tyrosine kinase that modulates Wnt signaling via interaction with frizzled receptors. In cancer genomics, it has been observed as a rare metastasis-specific loss-of-function event in colorectal cancer.
Alterations observed in the corpus
- Novel metastasis-specific Q304* nonsense mutation in patient 3 of a paired primary/metastasis CRC cohort; functional relevance speculative (Wnt inhibition via frizzled); no other CRC nonsense mutations reported in TCGA PMID:25164765
Cancer types (linked)
- CRC: rare metastasis-private nonsense mutation; functional significance unproven PMID:25164765
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- PTK7 Q304* functional relevance is unproven; no other CRC nonsense mutations at this gene reported in TCGA PMID:25164765
Sources
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