PTPRK
Overview
PTPRK (Protein Tyrosine Phosphatase Receptor Type K) encodes a receptor-type protein tyrosine phosphatase that functions as a TGF-beta transcriptional target. It has been identified as a recurrently mutated gene in sun-exposed cutaneous melanoma, suggesting a role as a tumor suppressor in this context.
Alterations observed in the corpus
- Missense mutations in 19.7% of sun-exposed melanomas in 147-tumor Yale WES cohort; protein tyrosine phosphatase and TGF-beta transcriptional target PMID:22842228
- Frameshift L457fs and 4 homozygous deletions observed in ACC; classified as a tyrosine phosphatase tumor suppressor PMID:23685749
Cancer types (linked)
- Cutaneous melanoma (SKCM): missense mutations in 19.7% of sun-exposed tumors, making PTPRK one of the more frequently mutated phosphatases in this cancer type PMID:22842228
Co-occurrence and mutual exclusivity
- No specific co-occurrence or mutual exclusivity patterns reported beyond enrichment in sun-exposed melanoma subtype PMID:22842228
Therapeutic relevance
- No direct therapeutic targeting established; its role as a TGF-beta pathway effector may have implications for combination strategies.
Open questions
- Functional significance of PTPRK missense mutations in melanoma (tumor suppressor vs passenger) has not been experimentally validated.
Sources
This page was processed by entity-page-writer on 2026-05-06. - PMID:23685749
This page was processed by wiki-cli on 2026-05-09.