PTPRT
Overview
PTPRT (protein tyrosine phosphatase receptor type T) encodes a receptor-type phosphatase implicated as a tumor suppressor. PTPRT missense mutations have been observed in radiation-associated osteosarcoma.
Alterations observed in the corpus
- Missense mutations in 17% of RT-OS vs 7% of sporadic OS, indicating enrichment in radiation-associated osteosarcoma PMID:37350195.
Cancer types (linked)
- OS – PTPRT missense mutations enriched in RT-OS (17%) compared to sporadic OS (7%) PMID:37350195.
Co-occurrence and mutual exclusivity
- Not specifically reported in the corpus for PTPRT partners PMID:37350195.
Therapeutic relevance
- No PTPRT-directed therapy is reported in this corpus PMID:37350195.
Open questions
- The functional significance of PTPRT missense mutations in RT-OS and their potential interaction with other RT-OS alterations (e.g., FGFR1 amplification) are not established PMID:37350195.
Sources
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