PVT1
Overview
PVT1 is a long non-coding RNA gene at chromosome 8q24 frequently involved in structural rearrangements in cancer. In medulloblastoma, recurrent rearrangements targeting PVT1 are identified as candidate driver events.
Alterations observed in the corpus
- Recurrent structural rearrangements targeting PVT1 identified in a 491-sample WGS/WES pan-medulloblastoma cohort alongside rearrangements targeting PTEN and GLI2 PMID:28726821
Cancer types (linked)
- MB: recurrent SV target identified in pan-MB integrative genomic analysis PMID:28726821
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- The functional consequence of PVT1 rearrangements in medulloblastoma (e.g., MYC activation via enhancer proximity vs. lncRNA loss-of-function) is not resolved in this study.
Sources
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