RAD17
Overview
RAD17 (RAD17 checkpoint clamp loader component) is a key component of the DNA damage checkpoint pathway. It loads the RAD9-RAD1-HUS1 (9-1-1) clamp onto DNA at sites of damage and is required for proper ATR-mediated checkpoint activation. Mutations that disrupt RAD17 function impair DNA damage sensing and may contribute to genomic instability and hypermutation.
Alterations observed in the corpus
- Nonsense mutations observed in NSCLC tumors from pembrolizumab-treated patients; required for proper DNA damage response; found in DCB patients in a cohort where high mutation burden predicts benefit from anti-PD-1 therapy PMID:25765070
Cancer types (linked)
- NSCLC: Nonsense mutations in pembrolizumab-treated cohort; observed in DCB patients PMID:25765070
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Defective DNA damage response via RAD17 loss may contribute to elevated tumor mutation burden, which predicts durable clinical benefit from pembrolizumab in NSCLC PMID:25765070
Open questions
Sources
This page was processed by crosslinker on 2026-05-14.