RAD50
Overview
RAD50 encodes a component of the MRN (MRE11-RAD50-NBN) complex, essential for DNA double-strand break recognition and repair, as well as telomere maintenance. In endometrial cancer, RAD50 protein expression differences across molecular subtypes suggest subtype-specific variation in DNA repair capacity.
Alterations observed in the corpus
- RAD50 shows elevated RPPA protein expression in the copy-number-low endometrial carcinoma subgroup, suggesting differences in DNA repair capacity across endometrial cancer subtypes PMID:23636398
- CDK12, FANCA, PALB2, and RAD50 are additional somatic HR pathway genes identified in advanced prostate cancer (locoregional through mCRPC); combined germline+somatic HR-deficiency rate was 27% across canonical DDR genes PMID:28825054
Cancer types (linked)
- UCEC: RAD50 protein level (by RPPA) is elevated in copy-number-low endometrioid tumors relative to other endometrial cancer subgroups PMID:23636398
Co-occurrence and mutual exclusivity
- Copy-number-low endometrial subgroup (elevated RAD50) is enriched for CTNNB1 and PTEN mutations and low TP53 mutation rate PMID:23636398
Therapeutic relevance
- Elevated DNA repair capacity in copy-number-low endometrial cancers (inferred from RAD50 RPPA expression) may influence sensitivity to platinum-based chemotherapy or PARP inhibitors.
Open questions
- Whether RAD50 elevation reflects increased protein expression, gene amplification, or post-translational regulation is not specified in this cohort.
Sources
This page was processed by crosslinker on 2026-05-09. - PMID:28825054
This page was processed by entity-page-writer on 2026-05-15.