RAF1

Overview

RAF1 (CRAF) is a serine/threonine kinase in the RAS–MAPK signaling pathway. It is cataloged among somatic alterations in the mutational landscape of hepatocellular carcinoma (HCC) derived from large-scale whole-exome sequencing studies.

Alterations observed in the corpus

  • RAF1 is listed in the HCC mutational gene catalog from WES of 1,289 patients; individual mutation frequency is not separately enumerated in the review text. PMID:24798001
  • In mCRPC, RAF1 is involved in potentially actionable fusions (~3% of patients) that are candidates for pan-RAF or MEK inhibitor strategies. PMID:26000489
  • In cutaneous melanoma (SKCM), RAF1 is a recurrent fusion partner: TRAK1-RAF1, RAF1-AGGF1, and CLCN6-RAF1 fusions identified with intact kinase domain; enriched in the Triple-WT subtype. Functional validation of transforming activity and drug sensitivity awaits follow-up. PMID:26091043
  • Identified as a significantly mutated gene exclusively in lung ADC vs other TCGA tumor types (q < 0.1) in the 1,144-tumor NSCLC landscape study (660 lung ADC, 484 lung SqCC); contributes to the RTK/Ras/Raf pathway driver landscape in lung adenocarcinoma. PMID:27158780
  • 2 S257L hotspot mutations identified in a prospective LUAD cohort (860 patients, MSK-IMPACT panel); classified as unmatched driver alteration PMID:28336552

Cancer types (linked)

  • HCC — identified in comprehensive WES-based mutational profiling (n=1,289). PMID:24798001

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity data reported in the current corpus.

Therapeutic relevance

  • No direct RAF1-targeted therapy data reported in the current corpus. RAF1/BRAF pathway is a component of sorafenib’s multi-kinase inhibition profile. PMID:24798001

Open questions

  • Individual mutation frequency and functional significance of RAF1 alterations in HCC require further characterization.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:26000489

This page was processed by crosslinker on 2026-05-14. - PMID:26091043

This page was processed by crosslinker on 2026-05-14. - PMID:27158780

This page was processed by wiki-cli on 2026-05-14. - PMID:28336552

This page was processed by wiki-cli on 2026-05-14.