RAI14

Overview

RAI14 (retinoic acid-induced protein 14) encodes a cytoskeletal-associated protein involved in cell adhesion and actin organisation. It has been identified as a gene with alterations in acral melanoma genomic profiling.

Alterations observed in the corpus

  • Listed among genes with alterations in the acral melanoma (ALM) integrated genomic analysis cohort (34 patients; WGS + RNA-seq + SNP array) PMID:28373299.

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Observed in the ALM cohort context; specific co-mutation patterns not detailed PMID:28373299.

Therapeutic relevance

  • No targeted therapy reported for RAI14 alterations in this corpus PMID:28373299.

Open questions

  • The functional significance of RAI14 alterations in acral melanoma has not been established PMID:28373299.

Sources

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