RAN

Overview

RAN (RAs-related Nuclear protein) is a GTPase essential for nucleocytoplasmic transport, cell cycle progression, and mitotic spindle assembly. In cancer genomics, it has been identified as a component of a prognostic gene expression signature in hepatocellular carcinoma.

Alterations observed in the corpus

• RAN is part of a 5-gene tumor score (TAF9, RAN, RAMP3, KRT19, HN1) that predicts HCC recurrence and survival after resection PMID:24735922

Cancer types (linked)

• Hepatocellular carcinoma (HCC): component of a recurrence-prediction gene score PMID:24735922

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24735922

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