RAP1GAP
Overview
RAP1GAP (RAP1 GTPase-Activating Protein) is a GTPase-activating protein that negatively regulates RAP1, a RAS-family GTPase involved in cell adhesion, proliferation, and differentiation. RAP1GAP has been implicated as a tumor suppressor in thyroid cancer, where its loss may contribute to dysregulated RAP1 and downstream signaling. The TCGA integrated genomic characterization of papillary thyroid carcinoma (PTC) identified RAP1GAP as a gene with somatic alterations in PTC.
Alterations observed in the corpus
- RAP1GAP is listed among the genes with somatic alterations in papillary thyroid carcinoma (PTC) in the TCGA PTC cohort (n=496), identified in the context of the comprehensive multiplatform genomic characterization. PMID:25417114
Cancer types (linked)
- THPA (Papillary Thyroid Carcinoma): RAP1GAP carries somatic alterations in PTC identified by TCGA comprehensive genomic analysis. Specific prevalence and mutation class details are not reported in the wiki summary of this paper. PMID:25417114
Co-occurrence and mutual exclusivity
- Co-mutation context with major MAPK drivers (BRAF V600E, RAS) has not been explicitly described in the extracted data.
Therapeutic relevance
- No direct therapeutic targeting of RAP1GAP has been described in the corpus.
Open questions
- Frequency and functional impact of RAP1GAP alterations in PTC require detailed characterization beyond the TCGA gene list.
- Whether RAP1GAP loss cooperates with MAPK-pathway drivers in PTC is not established.
Sources
- PMID:25417114 — TCGA integrated genomic characterization of 496 papillary thyroid carcinomas.
This page was processed by crosslinker on 2026-05-14.