RBFOX1
Overview
RBFOX1 (RNA Binding Fox-1 Homolog 1) encodes an RNA-binding protein that regulates alternative splicing in neurons and muscle. In cancer, RBFOX1 alterations have been identified in melanoma, where its large genomic footprint makes it susceptible to somatic structural variation.
Alterations observed in the corpus
- Somatic mutations identified in melanoma WGS (25 tumors); implicated as part of the mutational landscape of cutaneous melanoma PMID:22622578
Cancer types (linked)
- Melanoma: somatic alterations observed in WGS discovery cohort PMID:22622578
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Whether RBFOX1 alterations are driver events or passenger mutations in melanoma is unresolved; the large genomic span of the locus increases probability of incidental mutation.
Sources
This page was processed by entity-page-writer on 2026-05-06.