RBL1

Overview

RBL1 (RB transcriptional corepressor like 1), also known as p107, is a member of the retinoblastoma protein family that regulates the cell cycle by controlling E2F transcription factor activity. Along with RB1 and RBL2, it forms the pocket protein family that controls G1/S transition. In small cell lung cancer, RBL1 undergoes inactivating translocations and mutations, contributing to cell cycle dysregulation.

Alterations observed in the corpus

• Inactivating translocations and mutations in small cell lung cancer (SCLC); member of the pan-Rb family inactivation pattern observed in SCLC alongside RB1 and RBL2. PMID:26168399

Cancer types (linked)

• Small cell lung cancer (SCLC): Inactivating translocations and mutations. PMID:26168399

Co-occurrence and mutual exclusivity

• Inactivated alongside RB1 and RBL2 as part of widespread Rb-family inactivation in SCLC. PMID:26168399

Therapeutic relevance

Open questions

Sources

• PMID:26168399

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