RBL2
Overview
RBL2 (RB transcriptional corepressor like 2), also known as p130, is a member of the retinoblastoma protein family involved in cell cycle control and differentiation. It represses E2F-dependent gene expression during quiescence. In small cell lung cancer, RBL2 undergoes inactivating translocations and mutations, and has been validated as an accessory tumour suppressor in mouse models (TKO mice show shorter SCLC latency when RBL2 is lost).
Alterations observed in the corpus
- Inactivating translocations and mutations in small cell lung cancer (SCLC); validated as an accessory tumour suppressor in TKO mice, where loss of RBL2 results in shorter SCLC latency. PMID:26168399
- Co-deleted with Rb1/Trp53 in murine triple-knockout (TKO) SCLC models used to corroborate findings on EZH2-SLFN11-mediated chemoresistance PMID:28196596
Cancer types (linked)
- Small cell lung cancer (SCLC): Inactivating translocations and mutations; functional validation in mouse models. PMID:26168399
Co-occurrence and mutual exclusivity
- Inactivated alongside RB1 and RBL1 as part of widespread Rb-family inactivation in SCLC. PMID:26168399
Therapeutic relevance
Open questions
Sources
This page was processed by entity-page-writer on 2026-05-14. - PMID:28196596
This page was processed by wiki-cli on 2026-05-14.