RBM46
Overview
RBM46 (RNA Binding Motif Protein 46) is an RNA-binding protein. It was identified as a MutSig/inactivation-bias hit in aggressive cutaneous squamous cell carcinoma, though with low allelic fractions suggesting it may be a passenger rather than a driver.
Alterations observed in the corpus
- RBM46 identified as a MutSig/inactivation-bias hit in aggressive cSCC (39 patients, whole exome sequencing); notably had low allelic fractions suggesting it may be a passenger rather than a driver PMID:25303977
Cancer types (linked)
- cSCC — identified by inactivation-bias significance methods; passenger status uncertain PMID:25303977
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Whether RBM46 mutations are true drivers or passengers in cSCC remains unresolved; low allelic fractions favor a passenger interpretation PMID:25303977
Sources
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