RGS7
Overview
RGS7 (Regulator of G-protein Signalling 7) encodes a member of the RGS family that accelerates GTPase activity of Gi/o-class G-protein alpha subunits, thereby modulating G-protein-coupled receptor (GPCR) signalling. In cancer genomics, RGS7 has been identified as a significantly mutated gene in small cell lung cancer (SCLC), though its precise oncogenic or tumour-suppressive role remains to be functionally characterised.
Alterations observed in the corpus
- Identified as a significantly mutated gene (q < 0.05) by whole-genome sequencing of 110 SCLC tumours; involved in G-protein-coupled receptor signalling alongside co-significant gene FPR1 PMID:26168399
Cancer types (linked)
- SCLC: recurrent somatic mutations detected in WGS cohort (n=110); biological role in SCLC pathogenesis unclear and listed as a gene requiring functional follow-up PMID:26168399
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- The biological significance of RGS7 mutations in SCLC is uncertain; the authors explicitly note that functional experiments are required to determine whether RGS7 acts as a driver PMID:26168399
Sources
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