RHOB

Overview

RHOB encodes a member of the Rho family of small GTPases involved in cytoskeletal organization, vesicle trafficking, and cell migration. Unlike other Rho GTPases, RHOB is frequently downregulated in cancer and has been proposed to function as a tumor suppressor that limits invasion and metastasis.

Alterations observed in the corpus

  • Identified as a mutated gene in bladder urothelial carcinoma (BLCA) in the TCGA comprehensive genomic characterization; specific alteration class noted in context of the significantly mutated gene landscape PMID:24476821

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • No specific co-mutation patterns reported in this corpus.

Therapeutic relevance

  • No direct therapeutic targeting reported in this corpus.

Open questions

  • Whether RHOB mutations in bladder cancer represent driver events or passengers requires functional characterization.

Sources

This page was processed by crosslinker on 2026-05-09.