RIPK4
Overview
RIPK4 (Receptor Interacting Serine/Threonine Kinase 4) is a kinase known to control keratinocyte differentiation. It was nominated as a novel candidate driver in cutaneous squamous cell carcinoma, with mutations clustering in the kinase and ankyrin repeat domains.
Alterations observed in the corpus
- RIPK4 mutated in 28% of UV-signature aggressive cSCC tumors; mutations clustered in kinase and ankyrin repeat domains; 35% truncating; nominated as a novel candidate driver; known to control keratinocyte differentiation PMID:25303977
- Squamous-differentiation regulator mutated in 7/29 (24%) metastatic cSCC samples including two truncating mutations; previously reported in head-and-neck SCC PMID:25589618
Cancer types (linked)
- cSCC — 28% mutation frequency in UV-signature tumors; significant by MutSig/inactivation-bias methods PMID:25303977
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Functional role of RIPK4 mutations in cSCC requires validation; whether mutations are activating or inactivating is not fully established PMID:25303977
Sources
This page was processed by entity-page-writer on 2026-05-11. - PMID:25589618
This page was processed by wiki-cli on 2026-05-14.