RIT1
Overview
RIT1 encodes a member of the Ras superfamily of small GTPases. It is recurrently mutated in lung adenocarcinoma and Noonan syndrome, and has been implicated as an oncogenic driver through activation of the MAPK and PI3K pathways. In cancer genomics, RIT1 mutations are rare but recurrent across several tumor types.
Alterations observed in the corpus
- Single-case p.Met107Val missense mutation detected in a sinonasal adenoid cystic carcinoma (AdCC) sequencing cohort; classified among rare single-case driver candidates PMID:24418857
- Activating mutations clustered around Q79 (homologous to RAS Q61) in 2% of LUAD (TCGA); exclusively in the oncogene-negative subset; transforms NIH3T3 cells and activates MAPK and PI(3)K signaling. PMID:25079552
- Identified as a significantly mutated gene exclusively in lung ADC vs other TCGA tumor types (q < 0.1) in the 1,144-tumor NSCLC landscape study (660 lung ADC, 484 lung SqCC); contributes to the RTK/Ras/Raf pathway driver landscape in lung adenocarcinoma. PMID:27158780
- Notably absent from the unmatched driver (UMD) cohort in the MSK prospective LUAD study (860 patients) despite enrichment in the TCGA UMD set; authors flag this discrepancy PMID:28336552
Cancer types (linked)
- ACYC: rare single-case missense alteration in sinonasal adenoid cystic carcinoma cohort PMID:24418857
Co-occurrence and mutual exclusivity
- Observed as isolated single-case event without noted co-mutation patterns PMID:24418857
Therapeutic relevance
- No direct therapeutic targeting reported in this corpus.
Open questions
- Functional significance of p.Met107Val in AdCC context is uncharacterized.
Sources
This page was processed by entity-page-writer on 2026-05-09. - PMID:25079552
This page was processed by wiki-cli on 2026-05-11. - PMID:27158780
This page was processed by wiki-cli on 2026-05-14. - PMID:28336552
This page was processed by wiki-cli on 2026-05-14.