RNF2
Overview
RNF2 (also known as RING1B) encodes a RING-domain E3 ubiquitin ligase that is the catalytic subunit of Polycomb Repressive Complex 1 (PRC1). It ubiquitinates histone H2A at lysine 119, a key mark for Polycomb-mediated gene silencing. RNF2 plays roles in stem cell identity, X-chromosome inactivation, and cancer cell differentiation. In the context of Ewing sarcoma, RNF2/RING1B has been identified as a cell-of-origin trait of human embryonic mesenchymal stem cells (heMSCs).
Alterations observed in the corpus
- Identified as a cell-of-origin trait of heMSCs (human embryonic mesenchymal stem cells) and retained in experimental EWS::FLI1-induced Ewing sarcoma tumors per spatial transcriptomics; previously linked to Ewing sarcoma biology by the same group PMID:25186949
Cancer types (linked)
- Ewing sarcoma: RNF2/RING1B expression marks the stem-cell phenotype associated with the proposed Ewing cell of origin PMID:25186949
Co-occurrence and mutual exclusivity
- Co-expressed with UCP2 and other heMSC stem-cell markers in experimental Ewing tumors PMID:25186949
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus.
Open questions
- Whether RNF2/RING1B expression levels are prognostic in primary Ewing sarcoma tumors remains uncharacterized.
Sources
This page was processed by entity-page-writer on 2026-05-11.