RPS27
Overview
RPS27 (Ribosomal Protein S27) is a component of the 40S small ribosomal subunit. Its 5′ TOP (terminal oligopyrimidine) element regulates translation downstream of the PI3K/AKT/mTOR pathway. In cutaneous melanoma, RPS27 was identified as a significantly mutated gene with UV-induced 5′ UTR hot-spots, implicating it as a potential melanoma driver.
Alterations observed in the corpus
- Ribosomal-protein significantly mutated gene (SMG) with UV-induced 5′ UTR hot-spots in ~9% of cutaneous melanoma cases; the 5′ TOP element regulates translation downstream of PI3K/AKT/mTOR signalling. Nominated as a melanoma driver but not yet functionally characterised. PMID:26091043
Cancer types (linked)
- SKCM: Mutation frequency ~9% with UV-signature hot-spots in the 5′ UTR; co-occurs with broader MAPK-pathway landscape. PMID:26091043
Co-occurrence and mutual exclusivity
- UV-induced mutation pattern places RPS27 in the UV-signature melanoma subset. PMID:26091043
Therapeutic relevance
- Potential connection to PI3K/AKT/mTOR pathway via 5′ TOP translational regulation; no direct therapeutic targeting established. PMID:26091043
Open questions
- Functional validation of RPS27 as a melanoma driver (vs. passenger mutated due to UV exposure) is outstanding. PMID:26091043
Sources
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