RRM1
Overview
RRM1 encodes the large subunit of ribonucleotide reductase and is a target of the nucleoside analog fludarabine. In the corpus it is nominated as a novel U-CLL driver.
Alterations observed in the corpus
- Novel U-CLL-specific driver in the 1,148-patient CLL map; target of fludarabine PMID:35927489.
Cancer types (linked)
- Chronic lymphocytic leukemia (CLLSLL) — novel U-CLL driver PMID:35927489.
Co-occurrence and mutual exclusivity
- Enriched in IGHV-unmutated (U-CLL) subtype PMID:35927489.
Therapeutic relevance
- RRM1 is the molecular target of fludarabine; mutations potentially relevant to chemoresistance PMID:35927489.
Open questions
- Functional validation of RRM1 as a CLL driver and its interaction with fludarabine sensitivity is deferred to future work PMID:35927489.
Sources
This page was processed by crosslinker on 2026-04-08.