RSF1

Overview

RSF1 (Remodeling and Spacing Factor 1) encodes a chromatin remodeling protein that forms part of the RSF complex involved in nucleosome remodeling. Located at 11q14.1, RSF1 is frequently co-amplified with PAK1 as part of the 11q13/14 amplicon cassette in breast cancer, particularly in the ER-positive IntClust 2 subgroup.

Alterations observed in the corpus

  • Amplified in the 11q13/14 cis-acting amplicon cassette alongside PAK1 in IntClust 2 breast cancers (predominantly ER-positive); 34-39/45 IntClust 2 cases amplified at this locus PMID:22522925

Cancer types (linked)

  • Breast cancer (ER-positive, IntClust 2): recurrent focal amplification at 11q14.1 as part of the 11q13/14 cassette PMID:22522925

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • The 11q13/14 amplicon defines a high-risk ER-positive subgroup (IntClust 2) that may warrant distinct therapeutic approaches beyond standard ER-positive classification.

Open questions

  • Specific functional contribution of RSF1 amplification versus co-amplified genes (PAK1, CCND1, EMSY) to the IntClust 2 phenotype is not fully delineated.

Sources

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