S1PR2
Overview
S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a G protein-coupled receptor that mediates signaling downstream of sphingosine-1-phosphate (S1P) and bile acids such as taurocholic acid. In cholangiocarcinoma, S1PR2 activation triggers pro-tumorigenic ERK/AKT/NF-kB signaling and induces PTGS2 (COX-2) expression, contributing to immune evasion and tumor invasiveness.
Alterations observed in the corpus
- Taurocholic-acid–activated S1PR2 triggers ERK/AKT/NF-kB signaling and PTGS2 (COX-2) induction in cholangiocarcinoma, suppressing CD8+ T-cell activity and recruiting regulatory T cells; JTE-013 antagonist suppresses tumor invasiveness in preclinical models PMID:25608663
Cancer types (linked)
- Cholangiocarcinoma (CCA): Pro-tumorigenic signaling via ERK/AKT/NF-kB and COX-2 induction; S1PR2 antagonism (JTE-013) has preclinical anti-invasive activity PMID:25608663
Co-occurrence and mutual exclusivity
- Co-acts with PTGS2 (COX-2) downstream in cholangiocarcinoma to suppress anti-tumor immunity PMID:25608663
Therapeutic relevance
- JTE-013 (S1PR2 antagonist) suppresses tumor invasiveness in preclinical CCA models PMID:25608663
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Sources
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