SCN11A

Overview

SCN11A (Sodium Voltage-Gated Channel Alpha Subunit 11) encodes the Nav1.9 voltage-gated sodium channel subunit, expressed primarily in peripheral sensory neurons. In cancer genomics, SCN11A has been identified as a somatically mutated gene in prostate cancer, though its functional significance as a driver is uncertain.

Alterations observed in the corpus

• Novel somatically mutated gene identified in prostate cancer WES (112 tumors); not previously known to be somatically altered in prostate cancer PMID:22610119

Cancer types (linked)

• Prostate cancer: novel somatic mutations identified in WES cohort of 112 tumors PMID:22610119

Co-occurrence and mutual exclusivity

• No co-occurrence or mutual exclusivity data reported in the corpus.

Therapeutic relevance

• No direct therapeutic associations reported in the corpus.

Open questions

• Driver vs. passenger status of SCN11A mutations in prostate cancer is unresolved; functional characterization is needed.

Sources

• PMID:22610119

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