SCN9A

Overview

SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9) encodes a voltage-gated sodium channel involved in pain signaling. Gain-of-function mutations cause primary erythermalgia; loss-of-function causes congenital insensitivity to pain. It has been identified in the HNSCC TCGA cohort as a gene with at least one identical previously COSMIC-reported mutation.

Alterations observed in the corpus

• Gene with at least one identical previously COSMIC-reported mutation in the HNSCC TCGA cohort (n=279 tumors) PMID:25631445

Cancer types (linked)

• HNSCC: COSMIC-reported mutation observed in TCGA cohort PMID:25631445

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25631445

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