SEMA3E

Overview

SEMA3E (semaphorin 3E) encodes a secreted class-3 semaphorin involved in axon guidance, acting through plexin receptors. In pancreatic ductal adenocarcinoma, SEMA3E is co-amplified with SEMA3A, suggesting coordinate dysregulation of semaphorin signaling contributes to PDAC pathogenesis.

Alterations observed in the corpus

  • Co-amplified with SEMA3A in pancreatic cancer WES of 142 ICGC tumors; part of the broader axon guidance pathway dysregulation in PDAC PMID:23103869

Cancer types (linked)

  • Pancreatic ductal adenocarcinoma (PAAD): co-amplified with SEMA3A in a subset of tumors PMID:23103869

Co-occurrence and mutual exclusivity

  • Co-amplified with SEMA3A; both are class-3 semaphorins signaling through PLXNA1 in pancreatic cancer PMID:23103869

Therapeutic relevance

  • Therapeutics targeting semaphorin-plexin signaling represent unexplored candidates for PDAC treatment PMID:23103869

Open questions

  • Functional role of SEMA3E amplification in PDAC as driver versus passenger requires experimental validation PMID:23103869

Sources

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