SGK1
Overview
SGK1 (Serum/Glucocorticoid Regulated Kinase 1) is a serine/threonine kinase regulated by the PI3K/AKT pathway. In lymphomas, SGK1 functions as a tumor suppressor, particularly in germinal center B-cell (GCB) subtypes, where recurrent inactivating mutations have been identified.
Alterations observed in the corpus
- Recurrently mutated (nonsense, missense) in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL); acts as a tumor suppressor in GCB-subtype lymphomas identified by whole-genome/exome sequencing PMID:21796119
- WES of 55 DLBCL tumors identified recurrent SGK1 mutations in ~4% of cases, implicating PI3K/AKT signaling pathway dysregulation in diffuse large B-cell lymphoma PMID:22343534
- Preferentially mutated in GCB DLBCL; mutations associated with favorable survival across DLBCL subtypes PMID:28985567
Cancer types (linked)
- Diffuse large B-cell lymphoma (DLBCL): inactivating mutations; GCB-restricted pattern PMID:21796119
- Follicular lymphoma (FL): inactivating mutations PMID:21796119
Co-occurrence and mutual exclusivity
- GCB-restricted mutation pattern suggests co-occurrence with other GCB-enriched alterations such as EZH2 Y641 and KMT2D mutations PMID:21796119
Therapeutic relevance
- SGK1 loss may affect PI3K pathway signaling; potential implications for PI3K inhibitor sensitivity in GCB-DLBCL PMID:21796119
Open questions
- Mechanism by which SGK1 loss promotes lymphomagenesis in GCB B-cells remains to be elucidated.
Sources
This page was processed by entity-page-writer on 2026-05-06. - PMID:22343534
This page was processed by wiki-cli on 2026-05-06. - PMID:28985567
This page was processed by wiki-cli on 2026-05-15.