SIK2

Overview

SIK2 (Salt Inducible Kinase 2) is a serine/threonine kinase in the AMPK family. An in-frame kinase domain duplication of SIK2 was identified in lung adenocarcinoma in a tumor lacking other known oncogene mutations, suggesting it may be a novel oncogenic driver in this context.

Alterations observed in the corpus

• In-frame kinase domain duplication identified by WGS in a LUAD tumor lacking other known oncogene mutations; proposed as a novel driver candidate PMID:22980975

Cancer types (linked)

• LUAD: in-frame kinase domain duplication observed in 1 case (Broad WES/WGS cohort, 183 tumors) PMID:22980975

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional significance of SIK2 kinase domain duplication in LUAD has not been experimentally validated PMID:22980975

Sources

• PMID:22980975

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