SLC16A4

Overview

SLC16A4 encodes monocarboxylate transporter 5 (MCT5), a member of the solute carrier family 16 involved in transmembrane transport of monocarboxylates such as lactate and pyruvate. It was identified as a significantly mutated gene in pancreatic ductal adenocarcinoma, potentially linking metabolic transport dysregulation to PDAC pathogenesis.

Alterations observed in the corpus

  • Identified as a significantly mutated gene in pancreatic cancer WES of 142 ICGC tumors PMID:23103869

Cancer types (linked)

  • Pancreatic ductal adenocarcinoma (PAAD): significantly mutated; functional role in PDAC requires further characterization PMID:23103869

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity patterns reported in the corpus.

Therapeutic relevance

  • No direct therapeutic relevance reported in the corpus.

Open questions

  • Whether SLC16A4 mutations are drivers or passengers in PDAC, and their functional consequence for monocarboxylate transport and tumor metabolism, require investigation PMID:23103869

Sources

This page was processed by entity-page-writer on 2026-05-07.