SLC5A3
Overview
SLC5A3 (Solute Carrier Family 5 Member 3), also known as SMIT (Sodium/Myo-Inositol Transporter), is a membrane transporter linked to mitochondrial function. It was nominated as a significantly mutated gene in papillary renal cell carcinoma with evidence of tumor-suppressor function.
Alterations observed in the corpus
- SLC5A3 identified as a significantly mutated gene in papillary renal cell carcinoma (pRCC); three frameshift loss-of-function mutations plus one predicted-damaging point mutation; suggests a tumor-suppressor role linked to mitochondrial alterations PMID:25401301
Cancer types (linked)
- PRCC — significantly mutated; loss-of-function pattern with three frameshift mutations; functional role linked to mitochondrial biology PMID:25401301
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Oncogenic versus passenger status of SLC5A3 mutations in pRCC lacks functional characterization in cancer PMID:25401301
Sources
This page was processed by entity-page-writer on 2026-05-11.