SLIT2

Overview

SLIT2 (Slit Guidance Ligand 2) encodes a secreted extracellular matrix glycoprotein that functions as a ligand for ROBO receptors. In small cell lung cancer, SLIT2 was identified as a candidate novel tumor suppressor based on recurrent truncating and missense mutations, expanding the known landscape of SCLC-relevant axon guidance genes.

Alterations observed in the corpus

  • Truncating and missense mutations in 10% of SCLC tumors; candidate novel tumor suppressor in SCLC PMID:22941188
  • Identified as a significantly mutated axon guidance gene in pancreatic cancer WES of 142 ICGC tumors; SLIT2 encodes a secreted repulsive axon guidance ligand and is recurrently altered in pancreatic cancer PMID:23103869

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

  • Tumor suppressor function of SLIT2 in SCLC requires functional validation PMID:22941188

Sources

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