SMARCA1

Overview

SMARCA1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin, subfamily A, member 1) is a component of the SWI/SNF chromatin-remodeling complex. It functions as an ATP-dependent chromatin remodeler involved in transcriptional regulation. SMARCA1 has been identified as a significantly mutated gene in prostate cancer, particularly in tumors lacking ETS gene fusions.

Alterations observed in the corpus

  • Identified as a SWI/SNF complex member altered in approximately 5% of a 1,013-sample prostate cancer cohort, with enrichment in ETS-fusion-negative tumors PMID:29610475

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Co-altered with other SWI/SNF members (ARID1A, ARID2, ARID4A) in prostate cancer; enriched in ETS-fusion-negative tumors PMID:29610475

Therapeutic relevance

Open questions

Sources

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