SNRPD3
Overview
SNRPD3 encodes the small nuclear ribonucleoprotein D3 polypeptide, a core component of the spliceosome’s Sm protein ring. It is a constituent of U1, U2, U4, and U5 snRNPs and is essential for pre-mRNA splicing. Mutations in splicing-factor genes including SNRPD3 have been observed in lung adenocarcinoma.
Alterations observed in the corpus
- Co-listed with SF3B1 and CMTR2/FTSJD1 as recurrently mutated RNA-processing factors in lung ADC (LUAD) in a 1,144-NSCLC exome-sequencing cohort (660 ADC, 484 SqCC) PMID:27158780.
Cancer types (linked)
- LUAD: Recurrent mutations observed in association with the splicing-factor class of alterations in lung adenocarcinoma PMID:27158780.
Co-occurrence and mutual exclusivity
- Co-mutated with SF3B1 and CMTR2/FTSJD1 (cap-methyltransferase) in the lung ADC splicing-factor mutation cluster PMID:27158780.
Therapeutic relevance
- No direct targeted therapy reported in the corpus. Splicing-factor mutations may confer synthetic vulnerabilities to spliceosome-modulating compounds, but this was not tested in the citing study.
Open questions
- Individual mutation frequency of SNRPD3 in lung ADC was not individually quantified in the citing paper PMID:27158780.
Sources
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