STAC
Overview
STAC (SH3 and cysteine-rich domain) encodes a protein on chromosome 3p that is involved in calcium channel regulation. It is among the most strongly down-regulated genes in cis following engineered chromosome 3p deletion in AALE lung epithelial cells, implicating it as a potential haploinsufficiency target in squamous cell lung cancers with 3p deletions.
Alterations observed in the corpus
- Among the 3p-encoded genes most strongly down-regulated in cis after engineered chr_3p deletion in AALE cells (>15-fold at early passage; >13-fold at late passage), nominating STAC as a potential haploinsufficiency target in tumors with 3p loss PMID:29622463
Cancer types (linked)
- Pan-cancer: 3p deletion is observed broadly across cancer types; STAC is located at 3p21 and subject to cis down-regulation upon 3p loss PMID:29622463
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Whether STAC haploinsufficiency is functionally selected in 3p-deleted tumors, or is a collateral consequence of deletion of nearby driver genes (e.g., ROBO1), remains to be determined PMID:29622463
Sources
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